English

Background

Sepsis is a very common condition in emergency department patients. Fluid is regarded a cornerstone of treatment. Studies in septic shock in the intensive care unit and in patients with sepsis associated hypotension in the emergency department, have pointed towards benefit with fluid restriction.

The aim is: To test if an IV fluid restrictive protocol in ED patients with sepsis is feasible, i.e., if the protocol decreases the IV fluid volumes administered.

Methods

An investigator-initiated, multicenter, randomized, parallel-group, open-labeled, feasibility trial investigating volumes of fluid within 24 hours in 124 patients with sepsis allocated to two different IV fluid regimens enrolled at three emergency departments in Central Region Denmark: either standard care arm or fluid-restrictive arm.

Protocol – all versions

ClinicalTrials.gov Identifier: NCT05076435

EudraCT Number: 2021-000224-35